Darunavir (Prezista) Risk List

The following serious side effects have been associated with the use of darunavir given together with ritonavir (RTV). Contact your healthcare provider if you have any of the symptoms of liver problems that are listed and any skin changes with the symptoms listed below.

• People taking darunavir together with ritonavir may develop severe liver problems, which may be life-threatening. People who have increased liver function tests before starting darunavir and people with liver diseases such as Hepatitis B or C have an increased risk of worsening liver disease. If you are developing liver problems, you may have one or more of the following symptoms:
  • yellowing of the skin or whites of your eyes,
  • dark urine, and pain on the right side of your stomach,
  • loss of appetite, upset stomach or vomiting,
  • pale colored stools,
  • itchy skin.
• Rash, which may be severe or life-threatening? Contact your Healthcare Provider if you develop a rash.
• If you develop any skin changes with the following symptoms stop using DRV/rtv combination and contact your Health Care Provider right away:
  • Fever
  • Tiredness
  • Muscle or joint pain
  • Blisters
  • Mouth sores
  • Red or inflamed eyes.

Additional side effects include:

• Diarrhea
• Nausea
• Stomach pain
• Vomiting
• Headache
• Other changes in blood test results that may show problems with the liver , kidneys and cholesterol levels
• Inflammation of the pancreas. When the pancreas becomes inflamed, it can cause pain in the stomach, nausea, vomiting
• Joint stiffness and bone pains may occur, rarely death of bone tissue and collapse of the bone may occur.

Note: Before starting darunavir, you should inform your healthcare provider if you are allergic to sulfa medicines. Your healthcare provider can provide more complete information about the side effects of ritonavir (the medicine you need to take together with DRV).