Lopinavir/Ritonavir (Kaletra)

The following serious side effects are associated with the use of lopinavir/ritonavir:

• Abnormal heart rhythm and electrocardiogram (EKG) changes. These changes can lead to serious heart problems. Your risk for these problems may be higher if you:
  • Already have a history of abnormal heart rhythm or other types of heart disease
  • Take other medicines that can affect your heart rhythm while you take lopinavir/ritonavir

If you develop abnormal heart rhythm you may experience lightheadedness, fainting spells or an abnormal heart beat.

• Pancreatitis (inflammation of the pancreas), which may cause death. If you develop pancreatitis, you may have one or more of the following: Stomach pain, nausea, vomiting or abnormal pancreatic function blood tests
• Large increases in triglycerides and cholesterol in the blood
• Liver problems and worsening liver disease, which may result in death. People with these conditions may have abnormal liver function blood tests. If you are developing liver problems, you may have one or more of the following: yellowing of the skin or whites of your eyes, dark urine, pain on the right side of your stomach, loss of appetite, upset stomach or vomiting, pale colored stools, itchy skin.
• Rash, which could blister, and may be severe or life-threatening. Contact your Healthcare Provider if you develop a rash

Additional side effects may include:

• Abnormal bowel movements (stools), including loose or watery stools, upset stomach and stomach pain
• Feeling weak and tired
• Headache